Toa in Quarantine is the first Toa Tales storyline, centered on Tahu and his siblings (Kopaka, Lewa, Gali, Pohatu, Onua) in quarantine due to a virus outbreak on the island of Mata Nui.
Allusions to the story of BIONICLE, specifically during it's first year with the outbreak confirmed to be Makuta while Ahkmou is shown to be conspiring with it.
Syp The Mighty and iDs5621 reprise their roles as Tahu/Pohatu/Lewa and Onua from Misguided, though with voice portrayals inspired by those from the BIONICLE film Mask of Light rather than the direction of that series.
Additionally, iDs takes over as the voice of Kopaka from ChickenBond2, who portrayed the character in Misguided.
Unlike Misguided, this series exclusively features characters from BIONICLE rather than original ones.